Pain Research and Management

Volume 2017 (2017), Article ID 3829168, 5 pages https://doi.org/10.1155/2017/3829168 Research Article Characteristics and Etiologies of Chronic Scrotal Pain: A Common but Poorly Understood Condition Osamah Aljumaily,1,2 Hind Al-Khazraji,1 Allan Gordon,3 Susan Lau,1,4 and Keith A. Jarvi1,2,4,5 1Division of Urology, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada 2Murray Koffler Urologic Wellness […]

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Cocaine Use in the Infertile Male Population: A Marker for Conditions Resulting in Subfertility

Introduction: We sought to evaluate the incidence and effect of cocaine use in the infertile male population. Materials and Methods: Men presenting for fertility evaluation reporting cocaine usage were identified via prospectively collected database. Data were analyzed for usage patterns, reproductive history, associated drug use and medical conditions, hormonal and semen parameters. Results: Thirty-eight out of 4,400 (0.9%) men reported cocaine use. […]

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The relationship between sperm viability and DNA fragmentation rates

Background: In humans, sperm DNA fragmentation rates have been correlated with sperm viability rates. Reduced sperm viability is associated with high sperm DNA fragmentation, while conversely high sperm viability is associated with low rates of sperm DNA fragmentation. Both elevated DNA fragmentation rates and poor viability are correlated with impaired male fertility, with a DNA fragmentation rate of […]

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Chlamydial Infection and Its Role in Male Infertility

Introduction: Chlamydia trachomatis is an established cause of tubal factor infertility; however its role in male fertility is not as clear.We sought to determine the prevalence of Chlamydia in infertile men and evaluate its impact onmale reproductive potential. Materials and Methods: We compared the incidence of Chlamydia in our infertile male population with that reported in […]

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Effect of different cryoprotectant agents on spermatogenesis efficiency in cryopreserved and grafted neonatal mouse testicular tissue

Restoration of male fertility associated with use of the cryopreserved testicular tissue would be a significant advance in human and animal assisted reproductive technology. The purpose of this study was to test the effects of four different cryoprotectant agents (CPA) on spermatogenesis and steroidogenesis in cryopreserved and allotransplanted neonatal mouse testicular tissue. Hank’s balanced salt solution (HBSS) with 5% […]

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Quantitative Proteomics Reveals That Enzymes of the Ketogenic Pathway Are Associated with Prostate Cancer Progression

Prostate cancer is the most common malignancy and the second leading cause of cancer-related deaths in men. One common treatment is androgen-deprivation therapy, which reduces symptoms in most patients. However, over time, patients develop tumors that are androgen-independent and ultimately fatal. The mechanisms that cause this transition remain largely unknown, and as a result, there are no effective treatments against androgen-independent prostate cancer. […]

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Proteomic Profiling of Androgen-independent Prostate Cancer Cell Lines Reveals a Role for Protein S during the Development of High Grade and Castration-resistant Prostate Cancer

Background: The mechanisms that cause castration-resistant prostate cancer remain unknown. Results: Using high throughput proteomics and subsequent clinical validation, we identified Protein S as being elevated in high grade/advanced prostate cancer. Conclusion: Protein S is elevated in aggressive prostate cancer. Significance: Protein S expression could serve as a biomarker of aggressive prostate cancer. Download Full […]

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Varicocele surgery or embolization: Which is better?

Introduction: Varicocele remains the most commonly identified correctable cause of male factor infertility. Surgical correction is the most commonly performed technique to treat varicoceles with a technical failure rate of less than 5%. An attractive alternative to surgery is the selective catheterization and embolization of the gonadal vein. This data are limited by small series. Methods: We reviewed a total […]

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Characterization of the seminal plasma proteome in men with prostatitis by mass spectrometry

Background: Prostatitis is an inflammation of the prostate gland which affects approximately 10% of men. Despite its frequency, diagnosing prostatitis and monitoring patient response to treatment remains frustrating. As the prostate contributes a substantial percentage of proteins to seminal plasma, we hypothesized that a protein biomarker of prostatitis might be found by comparing the seminal plasma proteome of patients with […]

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Verification of Male Infertility Biomarkers in Seminal Plasma by Multiplex Selected Reaction Monitoring Assay

Seminal plasma is a promising biological fluid to use for noninvasive clinical diagnostics of male reproductive system disorders. To verify a list of prospective male infertility biomarkers, we developed a multiplex selected reaction monitoring assay and measured the relative abundance of 31 proteins in 30 seminal plasma samples from normal, nonobstructive azoospermia and post-vasectomy individuals. Median levels of some proteins were decreased by […]

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