Abstracts and Published Research, Dr. Mullen

John Brendan Maurice Mullen Publication (last 5 years) Bethune GC, Mullen JB, Chang MC. Detecting intratumoral heterogeneity in routine breast-HER2 testing: low yield of testing multiple blocks. Ann Diagn Pathol. 2015 Dec;19(6):385-90. doi: 10.1016/j.anndiagpath.2015.08.001. Epub 2015 Aug 15.   Abstract BACKGROUND: Intratumoral heterogeneity can lead to uncertainty in breast carcinoma HER2 testing, both with respect […]

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Prognostic factors for a favorable outcome after varicocele repair in adolescents and adults

Mary K Samplaski1, Keith A Jarvi2 INTRODUCTION The effect of varicocele repair on male fertility remains debatable.1 Though the majority of studies report that varicocele repair results in improved semen parameters, not all reports support this finding.2,3 The impact on natural pregnancy rates is even more controversial.1 Based on current evidence, both the American Urological Association (AUA) and the American […]

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CUA Guideline: The workup and management of azoospermic males

A committee was established at the request of the Canadian Urological Association to develop guidelines for the investigation and management of azoospermia. Members of the committee, all of whom have special expertise in the investigation and management of male infertility, were chosen from different communities across Canada. The members represent different practices in different communities. Introduction and background Infertility or subfertility affects […]

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Pathophysiology of fat embolism: A rabbit model.

Blankstein M, Byrick RJ, Richards RR, Mullen JB, Zdero R, Schemitsch EH. Pathophysiology of fat embolism: A rabbit model. J Orthop Trauma. 2011;25:674-80. Abstract OBJECTIVES: The objective of this study was to assess the effects of fat embolism on rabbit physiology. METHODS: After anesthetic administration, both femoral condyles of the right knee only of 23 […]

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Diagnosis and treatment of azoospermia resulting from testicular sar-coidosis.

Kovac JR, Flood D, Mullen JB, Fischer MA. Diagnosis and treatment of azoospermia resulting from testicular sarcoidosis. J Androl. 2012;33:162-6. Abstract Genitourinary sarcoidosis is uncommon, with only rare documented cases of testicular involvement reported. We detail the case of a 37-year-old male who initially presented for azoospermia and secondary infertility. A testicular biopsy revealed nonnecrotizing […]

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HER2 testing of multifocal invasive breast carcinoma: how many blocks are enough?

Bethune GC, Mullen JB, Chang MC. HER2 testing of multifocal invasive breast carcinoma: how many blocks are enough? Am J Clin Pathol. 2013;140:588-92. Abstract OBJECTIVES: To determine the diagnostic yield of testing multiple blocks for HER2 in cases of multifocal breast carcinoma.   METHODS: We identified 246 consecutive cases of multifocal invasive breast carcinoma in […]

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Influenza Primes Human Lung Microvascular Endothelium to Leak upon Exposure to Staphylococcus aureus.

Wang C, Armstrong SM, Sugiyama MG, Tabuchi A, Krauszman A, Kuebler WM, Mullen B, Advani S, Advani A, Lee WL. Influenza Primes Human Lung Microvascular Endothelium to Leak upon Exposure to Staphylococcus aureus. Am J Respir Cell Mol Biol. 2015 Oct;53(4):459-70. Abstract A major cause of death after influenza virus infection is lung injury due […]

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Detecting intratumoral heterogeneity in routine breast-HER2 testing: low yield of testing multiple blocks

Bethune GC, Mullen JB, Chang MC. Detecting intratumoral heterogeneity in routine breast-HER2 testing: low yield of testing multiple blocks. Ann Diagn Pathol. 2015 Dec;19(6):385-90. doi: 10.1016/j.anndiagpath.2015.08.001. Epub 2015 Aug 15. Abstract   BACKGROUND: Intratumoral heterogeneity can lead to uncertainty in breast carcinoma HER2 testing, both with respect to pathology reporting and clinical significance. The standard […]

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