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Tag: fertility issues

Foods That Help Sperm
Foods That Help To Improve Your Sperm There are certain foods that are especially good for you when you’re sensitive to enhancing your sperm to help support the creation of a baby. Things like… dark chocolate, walnuts, oysters, citrus fruits …and there are several more! We’ve listed 9. https://www.youtube.com/watch?v=g-qD9uPn9UM
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Azoospermia and Spermpredict
Azoospermia and Sperm Predict Approximately 10-15% of men struggling with interfertility are diagnosed with azoospermia, which means they have no sperm in their semen. Obstructive azoospermia (OA), caused by blockages in the reproductive tract, is responsible for 40% of cases, while the remaining 60% are due to issues with sperm production, known as non-obstructive azoospermia (NOA). NOA encompasses several subtypes
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Sperm DNA Quality
Sperm DNA Quality It has been determined that high rates of sperm DNA damage are associated with male infertility, decreasing pregnancy rates and increases in pregnancy loss rates. Sperm DNA fragmentation assessment is a valuable test, with high DNA damage being the single best sperm test to predict higher pregnancy loss rates. Infertile men with a sperm DNA fragmentation above
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What is sperm aneuploidy?
What is sperm aneuploidy? Typically sperm will have either 22 + X or 22 + Y chromosomes. Addition or loss of a single chromosome results in sperm aneuploidy. Sperm aneuploidy occurs due to errors during meiosis. Even perfectly fertile men have sperm with aneuploidy rates between 0.1 – 0.5% per chromosome per sperm. Aneuploidy rates may be 2 to 10
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Verification of male infertility biomarkers in seminal plasma by multiplex selected reaction monitoring assay
Verification of male infertility biomarkers in seminal plasma by multiplex selected reaction monitoring assay Seminal plasma is a promising biological fluid to use for noninvasive clinical diagnostics of male reproductive system disorders. To verify a list of prospective male infertility biomarkers, we developed a multiplex selected reaction monitoring assay and measured the relative abundance of 31 proteins in 30 seminal
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Differential diagnosis of azoospermia with proteomic biomarkers ECM1 and TEX101 quantified in seminal plasma
Differential diagnosis of azoospermia with proteomic biomarkers ECM1 and TEX101 quantified in seminal plasma Male fertility problems range from diminished production of sperm, or oligozoospermia, to nonmeasurable levels of sperm in semen, or azoospermia, which is diagnosed in nearly 2% of men in the general population. Testicular biopsy is the only definitive diagnostic method to distinguish between obstructive (OA) and
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Immunocapture-Selected Reaction Monitoring Screening Facilitates the Development of ELISA for the Measurement of Native TEX101 in Biological Fluids
Immunocapture-Selected Reaction Monitoring Screening Facilitates the Development of ELISA for the Measurement of Native TEX101 in Biological Fluids Monoclonal antibodies that bind the native conformation of proteins are indispensable reagents for the development of immunoassays, production of therapeutic antibodies and delineating protein interaction networks by affinity purification-mass spectrometry. Antibodies generated against short peptides, protein fragments, or even full length recombinant
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Preclinical evaluation of a TEX101 protein ELISA test for the differential diagnosis of male infertility
Preclinical evaluation of a TEX101 protein ELISA test for the differential diagnosis of male infertility Background: TEX101 is a cell membrane protein exclusively expressed by testicular germ cells and shed into seminal plasma. We previously verified human TEX101 as a biomarker for the differential diagnosis of azoospermia, and developed a first-of-its-kind TEX101 ELISA. To demonstrate the clinical utility of TEX101, in
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Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies
Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies TEX101 is a testis-specific protein expressed exclusively in male germ cells and is a validated biomarker of male infertility. Studies in mice suggest that TEX101 is a cell-surface chaperone which regulates, through protein-protein interactions, the maturation of proteins involved in spermatozoa transit and oocyte binding. Male
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