Proteomic Profiling of Androgen-independent Prostate Cancer Cell Lines Reveals a Role for Protein S during the Development of High Grade and Castration-resistant Prostate Cancer

Background:

The mechanisms that cause castration-resistant prostate cancer remain unknown.

Results:

Using high throughput proteomics and subsequent clinical validation, we identified Protein S as being elevated in high
grade/advanced prostate cancer.

Conclusion:

Protein S is elevated in aggressive prostate cancer.

Significance:

Protein S expression could serve as a biomarker of aggressive prostate cancer.

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