Proteomic Profiling of Androgen-independent Prostate Cancer Cell Lines Reveals a Role for Protein S during the Development of High Grade and Castration-resistant Prostate Cancer
Background:
The mechanisms that cause castration-resistant prostate cancer remain unknown.
Results:
Using high throughput proteomics and subsequent clinical validation, we identified Protein S as being elevated in high
grade/advanced prostate cancer.
Conclusion:
Protein S is elevated in aggressive prostate cancer.
Significance:
Protein S expression could serve as a biomarker of aggressive prostate cancer.
